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Association of apolipoprotein ɛ4 allele with hypertriglyceridemia in obesity
Author(s) -
Fumeron F.,
Rigaud D.,
Bertiere M. C.,
Bardon S.,
Dely C.,
Apfelbaum M.
Publication year - 1988
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1988.tb02873.x
Subject(s) - hypertriglyceridemia , apolipoprotein e , medicine , allele , endocrinology , obesity , odds ratio , apolipoprotein b , population , genetics , biology , triglyceride , cholesterol , gene , disease , environmental health
Hypertriglyceridemia is the most frequent lipid abnormality associated with obesity. Genetic polymorphism of apolipoprotein E (apoE) has been demonstrated to influence lipid levels. We wanted to assess the role of apoE alleles in the hypertriglyceridemias of the obese population. The apoE phenotypes and lipid status were investigated in a population of 172 obese French subjects. The frequencies of phenotypes E4/3, E4/4 and E4/2 were 29.7%, 8.1% and 2.1%, respectively, in a subgroup with triglycerides ≥ 200. mg/dl (n = 37) versus 14.2%, 2.7% and 0.9% in the normolipidemic subgroup (p< 0.005). The odds ratio of hypertriglyceridemia was 3.15 for obese subjects with ɛ4; 27.7% of hypertriglyceridemias could be attributed to ɛ4 allele. It is concluded that the genetic polymorphism of apoE modulates the effects of obesity on lipids and lipoproteins and that allele ɛ4 increases the risk of obesity‐induced hypertriglyceridemia.