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Evidence for a sperm mutation resulting in Duchenne muscular dystrophy
Author(s) -
Børresen A. L.,
Heiberg A.,
Møller P.,
Berg K.
Publication year - 1987
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1987.tb03352.x
Subject(s) - duchenne muscular dystrophy , mutation , muscular dystrophy , genetics , sperm , biology , medicine , gene
DNA analysis of Xp21 markers in a family with two brothers affected with Duchenne muscular dystrophy (DMD) revealed that the mutation most likely had occurred in a grandpaternal sperm. There is therefore a low risk that the maternal aunts and their daughters are carriers of the DMD gene.