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Autosomal recessive inheritance of idiopathic dilated cardiomyopathy in a Madeira Portuguese kindred
Author(s) -
Goldblatt J.,
Melmed J.,
Rose A. G.
Publication year - 1987
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1987.tb02803.x
Subject(s) - penetrance , dilated cardiomyopathy , expressivity , cardiomyopathy , genetics , medicine , inheritance (genetic algorithm) , biology , phenotype , heart failure , gene
Cardiomyopathy is a heterogeneous disorder with numerous inherited and acquired causes. Familial, isolated, dilated cardiomyopathy is usually reported as being inherited in an autosomal dominant mode with variable penetrance and expressivity: In this paper we describe a form of autosomal recessively inherited, dilated, cardiomyopathy occurring in three members of a consanguineous Madeira Portuguese family. Following review of the literature, it appears that the autosomal recessive form of dilated cardiomyopathy is more common than previously reported.