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Congenital cutis laxa with retardation of growth and motor development: a recessive disorder of connective tissue with male lethality
Author(s) -
Allanson Judith,
Austin William,
Hecht Frederick
Publication year - 1986
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1986.tb01236.x
Subject(s) - cutis laxa , growth retardation , connective tissue , medicine , connective tissue disorder , biology , dermatology , pathology , genetics , pregnancy
A syndrome of cutis laxa, ligamentous laxity and delayed motor development has been reported in 13 children. All are girls. Four are from Saudi Arabia. Another Saudi Arabian girl, the product of a consanguineous union, is described with intrauterine growth retardation, delayed closure of the anterior fontanel, slow motor development, cutis laxa and ligamentous laxity. The syndrome appears to be an autosomal recessive disorder of connective tissue, with male lethality.