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Population cytogenetics of autosomal fragile sites
Author(s) -
Petit P.,
Fryns J. P.,
Berghe H. van den,
Hecht F.
Publication year - 1986
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1986.tb01229.x
Subject(s) - chromosomal fragile site , cytogenetics , genetics , fragile x syndrome , biology , population , phenotype , chromosome , medicine , gene , environmental health
The present investigation deals with a population chromosomal survey for autosomal fragile sites under conditions of folate deprivation in 405 mental retardates. A total of 13 ascertainments of folate sensitive autosomal fragile sites is observed, of which 10q23 fragility appears to be the most frequent. Further cytogenetic studies of normal and retarded individuals are required to help elucidate the possible phenotypic effect of these autosomal sites and mental retardation.