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Inheritance of atrioventricular conduction time in Tokelau Islanders
Author(s) -
Griggs L. H.,
Chapman C. J.,
McHaffie D. J.
Publication year - 1986
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1986.tb00771.x
Subject(s) - polynesians , heritability , inheritance (genetic algorithm) , population , demography , biology , genetics , gene , sociology
The inheritance of A‐V conduction time in Polynesians has been examined, using ECGs taken from the population of the Tokelau Islands. As has been demonstrated in other racial groups, A‐V conduction time was influenced by sex, age, and heart rate. Complex segregation analysis provides evidence for a significant polygenic influence on A‐V conduction, but no evidence for a major gene. Familial correlations and commingling analysis are in agreement with this conclusion. The heritability of A‐V conduction time was 0.46. The hypothesis of M0ller & Heiberg (1980a) that a major gene could be influencing A‐V conduction, is not supported by these data.