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A study into possible deviation from the Hardy‐Weinberg equilibrium by the alleles of the hypervariable sequence in the region of the human insulin gene
Author(s) -
Hubbard A. L.,
Clayton J. F.
Publication year - 1986
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1986.tb00609.x
Subject(s) - hardy–weinberg principle , genetics , biology , allele , statistic , allele frequency , population , hypervariable region , sequence (biology) , population genetics , gene , statistics , mathematics , demography , sociology
A number of studies have reported on possible relationships between a hypervariable sequence near the 5′ end of the insulin gene and some common diseases. Control populations within these studies appear to disobey the Hardy‐Weinberg equilibrium. In this study we have ascertained the allele frequencies in 181 random individuals. The chi‐squared statistic comparing this population with a theoretical Hardy‐Weinberg population was 0.61. This makes it unlikely that in the general population the Hardy‐Weinberg rule is disobeyed. Possible reasons for the discrepancy between our study and the studies of others are discussed.