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Relative reliability of three different discriminant analysis methods for detecting PKU gene carriers
Author(s) -
Wenger S. L.,
Vieira P. W.,
Breck J. M.,
Steele M. W.
Publication year - 1986
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1986.tb00566.x
Subject(s) - linear discriminant analysis , discriminant function analysis , discriminant , reliability (semiconductor) , statistics , a priori and a posteriori , population , mathematics , medicine , artificial intelligence , computer science , physics , power (physics) , philosophy , environmental health , epistemology , quantum mechanics
A previously derived discriminant function for detecting classical PKU gene carriers without a priori pedigree probability was reevaluated using a large sample size. The test involves fluorometric measurement of fasting phenylalanine and tyrosine plasma levels. Among 75 controls and 45 known carriers, 95% could be classified as to their carrier status with greater than 98% accuracy. The accuracy of our method in classifying our population compared favorably to that of two other discriminant analysis methods requiring a priori probability.