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Linkage between the loci for cystic fibrosis and paraoxonase
Author(s) -
Schmiegelow K.,
Eiberg H.,
Tsui L. C.,
Buchwald M.,
Phelan P. D.,
Williamson R.,
Warwick W.,
Niebuhr E.,
Mohr J.,
Schwartz M.,
Koch C.
Publication year - 1986
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1986.tb00507.x
Subject(s) - paraoxonase , cystic fibrosis , allele , genetics , genetic linkage , linkage (software) , recombination fraction , medicine , biology , gastroenterology , gene , gene mapping , chromosome , oxidative stress
In a material of 22 Danish, 26 Canadian, 10 Australian, 5 English and 5 American families with at least 2 children affected with cystic fibrosis (CF) a combined positive LOD score of 3.46 was found for the relationship cystic fibrosis‐paraoxonase (PON) at recombination fraction θ= 0.07 in males and θ= 0.13 in females. Assuming a three allele model for PON the LOD score was 4.50 at the same recombination fractions. This confirms our earlier finding of an indication of CF‐PON synteny.