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Dermatoglyphic findings in patients with fragile X‐chromosome
Author(s) -
Hirth L.,
Singh S.,
Schilling S.,
Müller E.,
Goedde H. W.
Publication year - 1985
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1985.tb00197.x
Subject(s) - dermatoglyphics , mentally retarded , ridge , chromosomal fragile site , fragile x , chromosome , anatomy , medicine , biology , genetics , psychology , developmental psychology , paleontology , gene
Finger‐ and palmar prints of hemi‐ and heterozygote fragile X‐patients with mental retardation (10 males and 5 females) were compared to dermatoglyphic findings in 20 mentally retarded patients (10 males and 10 females) without fragile X and to 200 healthy unrelated persons (100 males and 100 females). Characteristic whorls and double‐loops with high ridge‐counts on finger‐tips and a pronounced transversal course of palmar ridges were restricted to males with fragile X. Female carriers of fragile X showed, corresponding to male patients, some abnormalities of the digital‐and palmar ridge‐pattern. Contrary to males, in carriers as well as in mentally retarded females without fragile X, fingerprints with low ridge‐counts were found. Common to all mentally retarded patients, but more pronounced in males with fragile X, abnormal palmar creases and hand‐measurements were observed. These findings probably are related to prenatal retarded growth of the length of the palma and of the middle‐finger.