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Analysis of a familial 15p + polymorphism: exclusion of Y/15 translocation
Author(s) -
Werner W.,
Herrmann F. H.
Publication year - 1984
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1984.tb04368.x
Subject(s) - chromosomal translocation , genetics , biology , centromere , heterochromatin , chromosome , karyotype , gene
A large 15p + chromosome with a whole heterochromatic short arm has been studied by means of different banding techniques in six of nine individuals of a family; a possible Y/15 translocation has been excluded. Furthermore a heteromorphic pair 9 has been observed in seven family members, representing a “possible” small partial inversion 9q12;pll or a centromeric variation. The transmission of these variant chromosomes as well as of some h + acrocentric chromosomes over three generations could be demonstrated. By means of AgI‐staining large intercellular variation of Ag‐NORs of the variant acrocentrics has been observed in the family members studied. The unusual accumulation of these variant chromosomes had no phenotypic effects.