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Fragile sites and chromosome breakpoints in constitutional rearrangements I. Amniocentesis
Author(s) -
Hecht Frederick,
Hecht Barbara K.
Publication year - 1984
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1984.tb04363.x
Subject(s) - breakpoint , chromosomal fragile site , genetics , biology , chromosome , chromosomal translocation , chromosomal rearrangement , meiosis , gene duplication , karyotype , gene
Since fragile sites may conceivably predispose to chromosome breakage and rearrangements in meiosis, we examined the locations of 278 breakpoints leading to chromosome rearrangements detected in amniocenteses. Of the 278 breakpoints. 59 (21%) were observed to be in bands containing fragile sites compared to an expectation of 31 (11%), a highly significant difference (P<0.001). The tendency for breakpoints to be in bands with fragile sites was independent of origin of the rearrangement or class of fragile site. consistent with the concept that fragile sites predispose to heritable chromosome rearrangements.