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Polymorphism at the Apoprotein‐E locus in relation to risk of coronary disease
Author(s) -
Cumming Alastair M.,
Robertson Forbes W.
Publication year - 1984
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1984.tb01995.x
Subject(s) - genotype , locus (genetics) , allele , myocardial infarction , medicine , genetics , coronary heart disease , biology , gene
The frequency of genotypes at the polymorphic locus which codes for Apoprotein‐E, an important constituent of very low density serum lipoprotein, has been determined in a random sample of persons between the ages of 45 and 60 years, born in the Grampian Region of North East Scotland. Three alleles, E II E III and E IV occur with a frequency of respectively 0.08, 0.77 and 0.15. In a random sample of survivors of myocardial infarction, born in the same region, genotype E IV E III occurs more and E III E II less frequently than expected. Also the mean age at first infarction is lower in men for genotype E IV E III than for other genotypes. Commonly occurring genotypes at this locus apparently influence the risk of coronary disease. A prospective study is needed to show how the genetic effects are expressed.