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Problems of detecting mosaicism in skin. A case of trisomy 8 mosaicism illustrating the advantages of in situ tissue culture
Author(s) -
Procter Susan E.,
Watt Jessie L.,
Lloyd David J.,
Duffty Paul
Publication year - 1984
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1984.tb01989.x
Subject(s) - trisomy , in situ , biology , aneuploidy , prenatal diagnosis , genetics , pathology , chromosome , fetus , medicine , pregnancy , chemistry , organic chemistry , gene
A case of mosaic trisomy 8 is described and the accuracy of flask culture and in situ culture techniques in detecting chromosomal mosaicism in tissues discussed. The advantages of the in situ method are illustrated and the importance of mixed colonies in defining mosaicism highlighted. The implications for prenatal diagnosis of mosaicism are pointed out.