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Epinephrine‐induced platelet aggregation. A twin study **
Author(s) -
Gaxiola Blanca,
Friedl Waltraut,
Propping Peter
Publication year - 1984
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1984.tb01101.x
Subject(s) - epinephrine , platelet aggregation , platelet , medicine , endocrinology , chemistry
A study in healthy adult male twin pairs (17 MZ, 15 DZ) was devised to examine the genetic influence on epinephrine‐induced platelet aggregation. Intraclass correlations of 0.65 for MZ, 0.43 for DZ, and 0.61 for repetitive experiments in the same subjects point to the influence of genetic factors. The antagonizing effect of phentolamine on platelet aggregation did not prove to be under genetic control. There was no significant correlation between epinephrine concentrations which induce half‐maximal aggregation and number of a‐adrenergic receptors as measured by 3 H‐yohimbine binding. In one MZ twin pair concordantly, and also in two unrelated persons, epinephrine was unable to induce complete platelet aggregation. This phenomenon is not related to the number of a‐adrenergic binding sites on platelets.