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The gene for apolipoprotein C‐ll is closely linked to the gene for apolipoprotein E on chromosome 19
Author(s) -
Humphries S. E.,
Berg K.,
Gill L.,
Cumming A. M.,
Robertson F. W.,
Stalenhoef A. F. H.,
Williamson R.,
Børresen A.L.
Publication year - 1984
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1984.tb01078.x
Subject(s) - restriction fragment length polymorphism , genetics , apolipoprotein b , biology , apolipoprotein c2 , taqi , linkage disequilibrium , apolipoprotein e , gene , genetic linkage , gene mapping , chromosome , microbiology and biotechnology , genetic marker , allele , lipoprotein , genotype , haplotype , very low density lipoprotein , cholesterol , biochemistry , medicine , disease
We have used a common TaqI restriction fragment length polymorphism (RFLP) near the human apolipoprotein C‐II (apoC‐II) gene to study linkage with apolipoprotein E (apoE). The inheritance of the apoC‐II RFLP was followed in seven families that were segregating for apoE protein variants. No recombinants were observed in 20 informative meioses, giving an overall lod score of > 4.0 at recombination fraction 0. We have also observed apparent linkage disequilibrium between apoE and the apoC‐II RFLP. Taken together these results demonstrate that these two apolipoprotein genes are closely linked and confirm that the gene for apoC‐II is on human chromosome 19.