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Confirmation of F13A assignment and sequence information concerning F13A‐HLA‐GLO
Author(s) -
Eiberg H.,
Nielsen L. S.,
Mohr J.
Publication year - 1984
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1984.tb01077.x
Subject(s) - sequence (biology) , genetics , human leukocyte antigen , combinatorics , computational biology , computer science , medicine , biology , mathematics , antigen
The polymorphism of the blood clotting factor F13A was examined in some of our Danish material of normal families. A total of four alleles were recognized, with allele frequencies as follows: F13A*1 =0.817, F13A*2 = 0.177, F13A*4 = 0.003 and a new allele F13A*5%0.003. The distribution of unrelated individuals did not deviate significantly from the Hardy‐Weinberg expectation. Linkage of F13A with HLA was confirmed (ẑ%5.18, θ=0.17 in males and ẑ%0.14, θ=0.37 in females). The sequence of the three systems F13A, HLA and GLO was found to be F13A‐HLA‐GLO as judged from two families each with a recombinant within the HLA system in males.