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Asymmetric skeletal anomalies in siblings
Author(s) -
Stanley Wayne S.,
Jr Mason Barr,
Hensinger Robert,
Ruby Stephen G.,
Dyke Daniel L. Van,
Weiss Lester
Publication year - 1984
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1984.tb00497.x
Subject(s) - etiology , medicine , prenatal diagnosis , pediatrics , pregnancy , fetus , genetics , biology
We describe two siblings with asymmetric limb reduction malformations. Such anomalies are usually considered to result from sporadic events, but the recurrence in siblings without any identifiable teratogenic insult suggests a genetic etiology. This finding becomes important when parents are counseled about future pregnancies. The use of prenatal diagnostic techniques during subsequent pregnancies should be considered.