Premium
Is there a predisposition for meiotic non‐disjunciton that may be detected by mitoitc hyperploidy?
Author(s) -
Staessen C.,
Maes A. M.,
KirschVolders M.,
Susanne C.
Publication year - 1983
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1983.tb02237.x
Subject(s) - aneuploidy , meiosis , heterochromatin , biology , genetics , trisomy , cytogenetics , chromosome , andrology , medicine , gene
The aneuploidy frequencies have been stuided in vitro in lymphocytes from couples with recurent abortions, from parents of a trisomic child and from control couples with at least two normal children; c‐heterochromatin variants have been analysed on the same samples by length measurements. A significant increase of hyeperploid cells has been observed in the lymphocytes from parents of a trisomic and couples with recurrent abortions as well. However, no consistent correlation has been found so far between c‐heterochromatin varients and an increase of aneuploidy.