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Replication and inactivation of and isodicentric X: presence of an inactive centromere influences the replication patterns
Author(s) -
Fryns J. P.,
Petit P.,
Klechzkowska A.,
Berghe H. van den
Publication year - 1983
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1983.tb02236.x
Subject(s) - centromere , replication (statistics) , biology , dna replication , genetics , chromosome , x chromosome , dna , virology , gene
An isodicentic X‐chromosome (idic(X)(pterq23::q23pter)) was found in a phenotypically normal 30‐year‐old female with symptoms of premature menopause. A study of DNA replication reveled that in a proportion of cells there was aasymmetric pattern of replication. The region with the inactive centromere had a tendency to replicate later that the portion with the functioning centromer.