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A linkage study of the HLA region using C‐band heteromorphisms
Author(s) -
Polacek Laurie A.,
Phillips Ruth B.,
Hackbarth Susan A.,
Duquesnoy Rene J.
Publication year - 1983
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1983.tb01869.x
Subject(s) - genetics , linkage (software) , lod score , genetic linkage , human leukocyte antigen , biology , centromere , chromosome , confidence interval , recombination , gene mapping , medicine , gene , antigen
A linkage study was performed to establish the map distance from the HLA region to the centromere on 6p. In this study, seven families were investigated for the segregation of their HLA types and a polymorphic C‐band marker on chromosome 6. Four out of 29 children were found to be recombinants. A map distance of 14 cM was determined. Ninety‐five percent confidence limits for the recombination frequency were established (0.012 ≤θ≤ 0.263).