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Δ‐Aminolevulinatedehydrase: synteny with ABO‐AK1‐ORM (and assignment to chromosome 9)
Author(s) -
Eiberg H.,
Mohr J.,
Nielsen L. Staub
Publication year - 1983
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1983.tb01864.x
Subject(s) - abo blood group system , synteny , chromosome , genetics , linkage (software) , biology , combinatorics , mathematics , gene
A material comprising 846 normal families from the Copenhagen area (fam. no. 604–1505) was tested for δ‐aminolevulinatedehydrogenase. Among the 1697 unrelated individuals (parents), the gene frequencies were 0.9378 for ALADH*1 and 0.0622 for ALADH*2. The distribution of phenotypes and the segregation ratios did not deviate significantly from the expected values. Linkage analysis was carried out for markers on chromosome 9, following up a hint of ALADH‐ORM linkage in part of the material. This was confirmed, and the most likely sequence, as judged from male θ values, was found to be ABO‐AK1 ‐ALADH‐ORM. The θ and ž values were as follows; ABO‐AK1 (θ=0.13, ž= 6.27), ABO‐ALADH (θ=0.21, ž= 5.38), ABO‐ORM (θ=0.27, ž=5.06), AK1‐ORM (θ=0.17, ž= 1.63), ALADH‐ORM (θ=0.13, ž= 7.05) and AK1‐ALADH (θ=0.11, ž= 2.45).