Premium
Glycinelserine ratios in amniotic fluid: an unreliable indicator for the prenatal diagnosis of nonketotic hyperglycinemia
Author(s) -
Mesavage Christine,
Nance Carol S.,
Flannery David B.,
Weiner Debra L.,
Suchy Sharon F.,
Wolf Barry
Publication year - 1983
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1983.tb00445.x
Subject(s) - hyperglycinemia , amniotic fluid , prenatal diagnosis , glycine , medicine , serine , fetus , obstetrics , pregnancy , endocrinology , chemistry , biochemistry , genetics , biology , amino acid , enzyme
A series of 183 amniotic fluid samples from pregnancies with normal outcome were examined to assess the validity of the glycine/serine ratio in the prenatal diagnosis of nonketotic hyperglycinemia. The glycine/serine ratios in our series span a range of values which includes those of the previously reported control group as well as those values of a fetus with nonketotic hyperglycinemia. These data indicate that the glycine/serine ratio in the amniotic fluid of a pregnancy at risk for nonketotic hyperglycinemia is not a reliable indicator for the prenatal diagnosis of this disorder.