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Group‐specific component (Gc) subtypes and schizophrenia
Author(s) -
Papiha S. S.,
Roberts D. F.,
McLeish L.
Publication year - 1982
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1982.tb01847.x
Subject(s) - allele , locus (genetics) , allele frequency , schizophrenia (object oriented programming) , biology , genetics , polymorphism (computer science) , medicine , gene , psychiatry
Two hundred and fifteen schizophrenic patients (108 males and 107 females) in northeast England have been investigated for Gc types and subtypes and compared with the frequencies in first‐degree relatives and controls. Böök et al. (1978) described Gc 2 allele association with schizophrenia. No such association was found with the Gc 2 allele in the present study although there is a tendency towards an increased frequency in females. In subtype allele frequencies the female patients showed a significant reduction of Gc IS allele. The results suggest a difference in susceptibility associated with the Gc locus in patients of different sexes.