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Platelet abnormalities in Down's syndrome
Author(s) -
More Raphael,
Amir Naomi,
Meyer Shirley,
Kopolovic Juri,
Yarom Rena
Publication year - 1982
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1982.tb01423.x
Subject(s) - platelet , calcium , medicine , abnormality , endocrinology , chemistry , psychiatry
Nine individuals with Down's syndrome and 12 normal children were studied. Platelets from Down's syndrome (DS) were smaller than normal and had reduced numbers and volumes of electron dense bodies. Whole cell and dense body calcium levels were lower than normal, while platelet surface net negative charge and anionic sites were found to be elevated in DS platelets. The findings suggest a calcium‐related membrane abnormality as one of the defects in DS platelets.