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A note on association of Bf and glomerulonephritis
Author(s) -
Papiha S. S.,
Rashid H. U.,
Roberts D. F.,
Kerr D. N. S.
Publication year - 1982
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1982.tb01414.x
Subject(s) - glomerulonephritis , allele , pathogenesis , genetic predisposition , genetics , disease , genetic association , immunology , biology , medicine , genotype , pathology , gene , kidney , single nucleotide polymorphism
In a study of 86 histologically defined glomerulonephritis patients, a striking association between the Bf F allele and glomerulonephritis has been found. There is also an enhanced genetic predisposition to glomerulonephritis in individuals with rare Bf alleles. The role of the chromosome 6 loci in the pathogenesis of the disease is emphasized.