Premium
Quantitative identification of banded human chromosomes
Author(s) -
Rum Rum,
Woodward A.,
Randell C.,
Koschel K.,
Hodgson G.S.
Publication year - 1982
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1982.tb01396.x
Subject(s) - biology , genetics , karyotype , similarity (geometry) , chromosome , identification (biology) , cytogenetics , computer science , artificial intelligence , gene , botany , image (mathematics)
A method of measuring the banding patterns of G‐banded human chromosomes is described. On the basis of the measurements, band profiles of normal human chromosomes were assembled, and normal chromosomes were tested against the mean profile to produce quantitated estimates of the similarities between individual chromosomes and the composite profiles. The tests produced greater than 90% agreement between allocation by eye and allocation by comparison with the profile. A statistical determination of similarity was produced, which could be used to recognize abnormal chromosomes.