Premium
Fragile site X chromosomes and X‐linked mental retardation in severely retarded boys in a northern Swedish county. A prevalence study
Author(s) -
Blomquist H. Kson,
Gustavson K.H.,
Holmgren G.,
Nordenson I.,
Sweins A.
Publication year - 1982
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1982.tb00965.x
Subject(s) - mentally retarded , chromosomal fragile site , trisomy , fragile x syndrome , fragile x , pediatrics , intellectual disability , x chromosome , medicine , genetics , chromosome , psychiatry , biology , psychology , developmental psychology , gene
In an unselected series of 96 severely mentally retarded boys (IQ < 50) born 1959–70 in a northern Swedish county, six had a fragile site on the distal end of the X chromosome (FraXq 28). The prevalence of the fragile X syndrome in severely retarded boys was 6 %. Next to trisomy 21, this fragile X syndrome appears to be the most common single cause of severe mental retardation in boys.