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Monoamine oxidase, phenylethylamine, norepinephrine and schizophrenia
Author(s) -
Wyatt Richard J.,
Karoum Farouk,
Stoff David M.,
Kleinman Joel E.,
Gillin J. Christian,
Jeste Dilip V.,
Potkin Steven G.
Publication year - 1981
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1981.tb00741.x
Subject(s) - paranoid schizophrenia , schizophrenia (object oriented programming) , norepinephrine , etiology , monoamine oxidase , monoamine oxidase inhibitor , medicine , peripheral blood , psychiatry , endocrinology , psychosis , psychology , chemistry , dopamine , biochemistry , enzyme
Summary The chain of events from decreased MAO activity in the peripheral blood of certain schizophrenic patients, particularly paranoid patients, to in creased concentrations of PEA, to increased NE and NE turnover in the brain of schizophrenic patients, may prove not to be as closely linked as the current hypothesis and available data suggest. Nevertheless, the notion that this chain exists is testable and provides an integrated hypothesis of etiology for a subgroup of schizophrenic patients.