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Platelet monoamine oxidase activity in schlzophrenic families‐kinetic aspects
Author(s) -
Koide Yayoi,
Sääf Jan,
Wahlund LarsOlof,
Roos Svante B.,
Wetterberg Lennart
Publication year - 1981
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1981.tb00735.x
Subject(s) - monoamine oxidase , platelet , endocrinology , medicine , chemistry , pharmacology , enzyme , biochemistry
Monoamine oxidase activity (MAO) was determined in platelets in samples from a North‐Swedish pedigree with a high frequency of schizophrenia. The MAO assay was performed with phenethylamine as substrate and with two concentrations of oxygen (0.06 and 0.12 mM). A tendency to lowered V max and increased apparent K m values was observed among the schizophrenic subjects, although there were no statistically significant differences in apparent K m and V max values between schizophrenics and their non‐schizophrenic relatives.