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Biochemical genetics of neurotransmitter enzymes and receptors: Relationships to schizophrenia and other major psychiatric disorders
Author(s) -
Ciaranello Roland D.,
Boehme Richard E.
Publication year - 1981
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1981.tb00727.x
Subject(s) - dopamine , biology , receptor , dopamine receptor , genetics , neurotransmitter , locus (genetics) , neurotransmitter receptor , d1 like receptor , neuroscience , dopamine receptor d3 , gene
Genetic control of catecholamine biosynthetic enzymes and dopamine receptors is described. The steady‐state levels of each of the catecholamine biosynthetic enzymes in the adrenal is regulated by a single genetic locus. The entire biosynthetic pathway gives the appearance of concerted inheritance under the control of a single locus. Mesolimbic and nigrostriatal dopamine receptors are also genetically regulated. Preliminary evidence suggests that agonist binding sites differ from antagonist sites in both brain regions, and that the genetic controls, which are expressed on receptor site number, are independent in the two brain regions.