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Increased amnionic fluid alpha‐fetoprotein due to a holoacardium amorphous twin
Author(s) -
Harger James H.,
Doshi Nalini,
Marchese Sandra,
Hinkle Richard S.,
Garver Kenneth L.
Publication year - 1981
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1981.tb00705.x
Subject(s) - alpha (finance) , neural tube , amniotic fluid , alpha fetoprotein , fetus , twin pregnancy , pregnancy , medicine , obstetrics , biology , surgery , embryo , genetics , construct validity , hepatocellular carcinoma , patient satisfaction
Amnionic fluid alpha‐fetoprotein measurement was employed as a screening test for neural tube defects in a pregnancy only at risk due to advanced maternal age. The alpha‐fetoprotein concentration was elevated more than 10 standard deviations above the mean and was found to be caused by a holoacardium amorphous twin. A normal female fetus was also present. Various causes of elevated alpha‐fetoprotein concentration in amnionic fluid are discussed.