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Variation in nucleolar organizer activity in lymphocytes of females with adenocarcinoma
Author(s) -
Cheng D. M.,
Denton T. E.,
Liem S. L.,
Elliot C. L.
Publication year - 1981
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1981.tb00687.x
Subject(s) - nucleolus organizer region , biology , adenocarcinoma , chromosome , staining , microbiology and biotechnology , nucleolar organizer region , gene , x chromosome , genetics , cancer
With the use of Ag staining and conventional light microscopy, a difference is visualized in the frequency of nucleolar organizer regions between PHA‐stimulated lymphocytes from normal females and females with various types of adenocarcinoma. This difference in NOR activity is more pronounced in G chromosomes than D chromosomes. It is feasible that rDNA gene activity in PHA‐stimulated lymphocytes is augmented in patients with adenocarcinoma due to the presence of plasma mediators arising from cellular malignancies. The NOR regions located on G chromosomes are considered to be more sensitive to these mediators than those on D chromosomes.