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Family analysis of Werner's syndrome: A survey of 42 Japanese families with a review of the literature
Author(s) -
Goto Makoto,
Tanimoto Kiyoaki,
Horiuchi Yoshihiko,
Sasazuki Takehiko
Publication year - 1981
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1981.tb00660.x
Subject(s) - werner syndrome , incidence (geometry) , genetics , medicine , linkage (software) , pediatrics , biology , gene , helicase , rna , physics , optics
Forty‐two Japanese families, including 80 individuals with Werner's syndrome were studied, confirming that this syndrome is inherited as an autosomal recessive trait. The incidence of malignancy was relatively high in these families and individuals with Werner's syndrome, although the incidence was not so high as was reported previously. HLA typing revealed no significant linkage with Werner's syndrome. The frequency of Werner's syndrome in Japan was estimated using two methods which indicated approximately 300 cases among 100 million people.