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Somatic cell genetic studies of the cystic fibrosis mucociliary inhibitor
Author(s) -
Mayo Brenda J.,
Klebe Robert J.,
Barnett Don R.,
Lankford B. J.,
Bowman Barbara H.
Publication year - 1980
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1980.tb02298.x
Subject(s) - cystic fibrosis , phenotype , biology , chromosome , somatic cell , genetics , fibroblast , gene , cell , genetic linkage , microbiology and biotechnology , cell culture
A series of cystic fibrosis homozygous fibroblast X mouse cell hybrids were constructed in order to determine the chromosome which carries the gene controlling the cystic fibrosis mucociliary inhibitor (CFMI) phenotype. Several hybrids and their subclones retained the CFMI phenotype for long periods in cell culture. Correlation of the CFMI phenotype with the presence of specific human chromosomes indicated that possible linkage existed between CFMI and human chromosomes 2, 4, 6, 10, and 18. The strongest chance of linkage existed for chromosome 4.