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Familial occurrence of chromosome 7/12 translocation
Author(s) -
Ming PenMing L.,
Parker Renee,
Goodner David M.
Publication year - 1980
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1980.tb01791.x
Subject(s) - chromosomal translocation , genetics , karyotype , biology , robertsonian translocation , chromosome , prenatal diagnosis , medicine , pregnancy , fetus , gene
A new balanced autosomal translocation, t(7;12) (p12;p13), was found in a high genetic risk family in which the mother is a translocation carrier. She had 12 pregnancies, six of which were terminated during the first trimester by spontaneous abortions. Among the six live births, three children inherited the translocation from their mother and were phenotypically normal. The father and three other children had normal karyotypes.