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Prader‐Willi syndrome and a bisatellited derivative of chromosome 15
Author(s) -
Wisniewski Lawrence P.,
Witt Mary E.,
GinsbergFellner Fredda,
Wilner Judith,
Desnick Robert J.
Publication year - 1980
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1980.tb01363.x
Subject(s) - derivative chromosome , genetics , derivative (finance) , biology , chromosome , endocrinology , medicine , karyotype , gene , economics , financial economics
A de novo bisatellited derivative of chromosome 15, inv dup (15) (pter→q11 or 12::p11 or q11 or 12 →pter), was identified by multiple banding techniques in a patient with Prader‐Willi syndrome. A comparison of familial no. 15 short arm polymorphisms indicated that the extra chromosome was the result of a non‐sister chromatid exchange between the paternal no. 15 homologs prior to or during meiosis.