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Elimination of an abnormal cell line from blood lymphocytes during post‐natal growth
Author(s) -
Fitzgerald Peter H.,
Mercer Jan M.
Publication year - 1980
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1980.tb00176.x
Subject(s) - abnormality , biology , chromosome , cell division , chromosomal abnormality , peripheral blood , cell , cell culture , blood cell , physiology , medicine , endocrinology , immunology , genetics , karyotype , psychiatry , gene
A cell line carrying an additional metacentric chromosome of unknown origin was present in PHA‐stimulated blood lymphocytes from a newborn female. The child had no marked physical or developmental abnormality but was small. The abnormal cell line, present in 20 % of blood cells at birth, progressively decreased and was absent by 16 months. Loss of the cell line appeared to involve a process of elimination rather than a chance event.