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The Wolf‐Hirschhorn syndrome
Author(s) -
Lurie I. W.,
Lazjuk G. I.,
Usaova Y. I.,
Presman E. B.,
Gurevich D. B.
Publication year - 1980
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1980.tb00167.x
Subject(s) - genetics , chromosomal translocation , biology , mutation , gene
Four new cases of the Wolf‐Hirschhorn syndrome are presented, two of which were due to t(4;22)mat. Review of the literature (more than 100 cases of the Wolf‐Hirschhorn syndrome) showed that 13 % of all the reported cases were not mutations but segregations of parental chromosomal aberrations, primarily translocations. Similar data were obtained previously for other deletions (5p‐, 18p‐, 18q ‐). Analysis of data on some “new” deletion syndromes (4q ‐, 8p‐, 9p‐, 10p‐, 11p ‐, 11q ‐) revealed that 14.5% were inherited cases. Thus, all human autosomal deletions have virtually the same genetic pattern.