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Trisomy 13 in bone marrow cells in acute myelocytic leukemia and myelofibrosis
Author(s) -
Hsu Lillian Y. F.,
Greenberg Michael L.,
Kohan Simona,
Wittman Ruth
Publication year - 1979
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1979.tb01742.x
Subject(s) - myelofibrosis , trisomy , bone marrow , pathology , haematopoiesis , leukemia , stem cell , trisomy 8 , myelocytic leukemia , myeloid leukemia , myeloid , medicine , cancer research , biology , cytogenetics , immunology , chromosome , genetics , gene
We have identified trisomy 13 in two additional patients with hematologic malignancies involving the hematopoietic stem cell: a 75–year–old female with acute myelocytic leukemia and a 64–year–old female with agnogenic myelofibrosis and myeloid metaplasia. Chromosome analysis of the direct bone–marrow preparation showed 100 % of cells with trisomy 13 in the first and 10 % of cells in the second. We also previously reported a patient with Phi negative chronic myelogenous leukemia in whom 100 % of the marrow cells showed an identical trisomy. The probability of finding three such patients in our case material was calculated to be 0.05–0.08, implying that trisomy 13 may be another nonrandom chromosomal aberration associated with malignancies of hematopoietic pluri–potent stem cell.