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Chromosome 8 abnormalities as components of neoplastic and hematologic disorders
Author(s) -
Riccardi Vincent M.,
Foroason Judy
Publication year - 1979
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1979.tb01741.x
Subject(s) - aneuploidy , abnormality , chromosome , karyotype , chromosome abnormality , chromosomal abnormality , pathology , biology , hematologic disorders , congenital malformations , sideroblastic anemia , genetics , medicine , immunology , bone marrow , pregnancy , gene , psychiatry
Publications involving patients with any abnormality of chromosome 8 have been reviewed in detail. For the time period involved, a total of 277 cases were found, including 74 instances of congenital aneuploidy, 130 instances of acquired aneuploidy, 38 instances of congenital rearrangements, and 35 instances of acquired rearrangements. A total of 170 cases of neoplastic and hematologic disorders were included; three were associated with congenital aneuploidy, two with congenital rearrangements, and the remaining 165 with acquired aberrations. The specific disorders ranged from sideroblastic anemia through chronic and acute leukemia to solid tumors. There appears to be a definite, though nonspecific correlation between congenital or acquired chromosome 8 abnormalities and the development of certain types of neoplastic growth.