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Genetic basis of acquired C4 deficiency
Author(s) -
Cream J. J.,
Olaisen B.,
Teisberg P.,
Soler A. V.,
Thompson R. A.
Publication year - 1979
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1979.tb01005.x
Subject(s) - human leukocyte antigen , disease , genetics , inheritance (genetic algorithm) , biology , medicine , gene , antigen
A study of the family of a patient who had an SLE‐like syndrome and an extremely low serum C4 revealed an inheritance of C4 types and HLA region markers which indicated that the patient had 60–70 % of “normal” C4 level prior to the onset of disease. Thus the extremely low C4 level during her disease may result from a combination of genetically determined low normal C4 and increased consumption/hyposynthesis secondary to her SLE.