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Discovery of an inherited bisatellited metacentric microchromosome in amniotic cell culture
Author(s) -
Romavn D. R.,
ColumbanoGReen L.,
Smythe R. H.,
Dukes P. C.
Publication year - 1979
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1979.tb00989.x
Subject(s) - microchromosome , amniocentesis , amniotic fluid , biology , pregnancy , andrology , genetics , fetus , prenatal diagnosis , karyotype , medicine , chromosome , gene
The identification is reported of an extra bisatellited metacentric microchromosome in amniotic cell culture from the third pregnancy of an identical twin (amniocentesis being performed because of age), and its subsequent finding in the maternal parent as an inherited familial marker. The carriers of the microchromosome are all clinically normal and the parents opted for continuation of pregnancy. Only one other report was found in the literature of a similar microchromosome detected in amniotic fluid culture, but we believe ours to be the first bisatellited microchromosome to be clearly identified from an amniotic cell culture using silver staining.