Premium
Evolutionary conservation of large chromosomal segments reflected in mammalian gene maps
Author(s) -
Lundin L.G.
Publication year - 1979
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1979.tb00855.x
Subject(s) - biology , genetics , gene , homologous chromosome , evolutionary biology , conserved sequence , gene silencing , genetic linkage , linkage (software) , base sequence
Conservation of genetic linkage over long periods of time is exemplified. Comparisons are made between chromosomal regions in different species as well as within two species, man and the house mouse. Homologous regions are defined and the phenomenon of differential silencing of genes is described. The importance of conservation of particular sequences of genes is discussed in relation to medical genetics, animal breeding, evolutionary theory and genetic regulation.