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Heterozygote advantage in cystic fibrosis: mosquito tests
Author(s) -
Super Maurice,
Schalkwyk DirkJ.
Publication year - 1979
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1979.tb00853.x
Subject(s) - heterozygote advantage , obligate , cystic fibrosis , biology , malaria , parasite hosting , immunology , genetics , genotype , gene , ecology , world wide web , computer science
Tests to demonstrate a preference by mosquitoes for stinging controls as opposed to obligate heterozygotes for Cystic Fibrosis proved negative. If a heterozygote advantage caused a lower malarial incidence in carriers in South West Africa, it must have worked through the malarial parasite being adversely affected by a serum factor. This remains to be tested.