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Double pre‐ß lipoprotein in ischaemic heart disease
Author(s) -
Postle A. D.,
Darmady J. M.,
Siggers D. C.
Publication year - 1978
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1978.tb04255.x
Subject(s) - myocardial infarction , medicine , cardiology , triglyceride , agarose gel electrophoresis , ischaemic heart disease , lipoprotein , coronary heart disease , cholesterol , endocrinology , biology , genetics , dna
The presence or absence of a double pre‐[5 lipoprotein (pre‐β 1 or pre‐β) peak on agarose gel electrophoresis was recorded in:a) 77 survivors of myocardial infarction, b) their first‐degree relatives, and c) 148 controls.Thirty‐nine percent of myocardial infarction survivors and 24 % of controls had pre‐β+ ( P < 0.05). The segregation of pre‐β 1 + in the families of myocardial infarction survivors was consistent with autosomal dominant inheritance. In the control group, fasting serum cholesterol and triglyceride values were higher in the pre β 1 + subjects, but the differences were not significant. We conclude that the presence of a double pre‐β lipoprotein peak on electrophoresis is associated with an increased risk of myocardial infarction.