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Large Y chromosome (Yq+) and increased risk of abortion
Author(s) -
Nielsen Johannes
Publication year - 1978
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1978.tb04140.x
Subject(s) - y chromosome , abortion , karyotype , genetics , gynecology , biology , chromosome , medicine , pregnancy , gene
Previous reports have indicated an association between Yq+ in the family and increased risk of abortion. In a chromosome investigation of 11,148 consecutively newborn children, we found 58 boys with a large Y chromosome (Y/F ≥ 1.00). The mothers of these boys had 22 % abortions, compared with 13 % among 4,895 mothers of children with normal karyotypes and without Yq+ ( P < 0.001).