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A cytogenetic survey of an institution for the mentally retarded: I. Chromosome abnormalities
Author(s) -
Jacobs Patricia A.,
Matsuura Janice S.,
Mayer Martha,
Newlands Irene M.
Publication year - 1978
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1978.tb04127.x
Subject(s) - mentally retarded , abnormality , chromosome , karyotype , genetics , biology , etiology , cytogenetics , chromosomal rearrangement , chromosome abnormality , medicine , psychology , pathology , psychiatry , developmental psychology , gene
A cytogenetic survey of 475 patients in an institution for the mentally retarded is reported. The chromosomes of all patients were studied using both a non‐banding and a G‐banding technique in order to estimate the relative efficiency of the two techniques in detecting structural rearrangements of the chromosomes. A total of 57 patients was found to have a chromosome abnormality, including five with a balanced structural rearrangement. The contribution of chromosome aberrations to the etiology of mental retardation is discussed with special emphasis on the contribution of balanced structural rearrangements.