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Prevalence of thyroid disorder in Down syndrome
Author(s) -
ŠAre Zlatko,
Ruvalcaba R. H. A.,
Kelley Vincent C.
Publication year - 1978
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1978.tb02121.x
Subject(s) - medicine , thyroid , goiter , thyroid function , thyroid disease , thyroid disorder , endocrinology , anti thyroid autoantibodies , thyroid function tests , pediatrics , physiology , antibody , autoantibody , immunology
Thyroid function has been studied in 121 patients between 13 and 48 years old with proven Down syndrome. Chemically, hypothyroidism was found in 17 % and hyperthyroidism in 2.5 % of the patients; 18 % of patients had goiter. Thyroid antibodies were detected in 33 % of subjects studied. The abnormal findings were almost equally distributed between the sexes above 20 years of age; however, females had significantly more thyroid disease than males in the younger age group.