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Biochemical investigations in cultured skin fibroblasts from patients with Duchenne muscular dystrophy
Author(s) -
Pena S. D. J.,
Vust A.,
Tucker D.,
Hamerton J. L.,
Wrogemann K.
Publication year - 1978
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1978.tb02060.x
Subject(s) - duchenne muscular dystrophy , fibroblast , muscular dystrophy , biology , pathology , microbiology and biotechnology , chemistry , cell culture , medicine , genetics
Cultured skin fibroblasts from patients with Duchenne muscular dystrophy were studied with a double‐labeling procedure. Preliminary evaluation of the growth characteristics and average viability of dystrophic cells did not show any major abnormalities. Analysis of doubly labeled fibroblast mixture did not disclose any consistent anomaly in the distribution of subcellular fractions or in the major protein components of dystrophic fibroblasts.

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